The Mona Lisa Leonardo da Vinci’s Mona Lisa is one of the most famous paintings of all time. And there has always been a discussion around her enigmatic smile. He used a trademark Renaissance technique called sfumato, which involves many thin layers of glaze mixed with subtle pigments. The striking result is that when you look directly at Mona Lisa’s smile, it seems to disappear. But when you look at the background your peripherals see a smiling face.