Erythritol may impair cellular functions essential to maintaining brain blood vessel health, according to researchers at the University of Colorado Boulder. Findings suggest that erythritol increases oxidative stress, disrupts nitric oxide signaling, raises vasoconstrictive peptide production, and diminishes clot-dissolving capacity in human brain microvascular endothelial cells.
Actual article https://journals.physiology.org/doi/abs/10.1152/japplphysiol.00276.2025
Just from the abstract caveats:
The study was in vitro (cultured cells).
The study treated it as if ingested erythritol (in a “beverage”) was 100% transported to the blood and not diluted by being in a larger volume.